By Christopher D. Stubbs, Emanuel Rubin (auth.), Christer Alling, Ivan Diamond, Steven W. Leslie, Grace Y. Sun, W. Gibson Wood (eds.)
Alcohol abuse and alcoholism are overseas difficulties whose expenditures cost-efficient ly, psychologically and medically were good documented. Alcohol is a different drug in that the results of over the top use may have a deleterious influence on so much if now not all organs of the physique. The mind is likely one of the organs most influenced through over the top alcohol intake. results at the mind might be visible in cognitive functionality, mind constitution and neurochemistry. over the last few years, there were major advances made in realizing how alcohol impacts mind neurochemistry. This e-book examines 4 significant parts, i. e. , membrane lipids, receptors and ion channels, moment messengers, and gene expression, the place major developments were made. The publication is split into 4 sections according to the 4 significant components. In each one part, information are tested that hide various ways from in vitro to in vivo stories. The part on membrane lipids comprises contemporary advancements in how ethanol impacts membrane ldl cholesterol domain names, polyunsaturated fatty acids, the reason and outcomes of phosphatidylethanol formation, and the modulation of membrane protein functionality by means of lipid-protein interplay. the second one part includes chapters on NMDA and 5-HT3 receptors, together with new elements on alcohol neurotoxicity and the molecular heterogeneity which can underlie adjustments in alcohol sensitivity in addition to chapters on GABA-gated chloride flux, and calcium channels.
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Additional resources for Alcohol, Cell Membranes, and Signal Transduction in Brain
Attie. 1988. Transbilayer movement of cholesterol in the human erythrocyte membrane. J. Lipid Res. 29. 481. Butko. • I. Hapala, T J. Scallen and F. Schroeder. 1990. Acidic phospholipids slrikingly potentiate sterol carrier protein 2 mediated intermembrane sterol cransfer. Biochern. 29. 4070. Chin. M. B. Goldstein. 1978. Increased cholesterol content of erythrocyte and brain membranes in ethanol-tolerant mice. 358. Chin. H. B. Goldstein. 1977. Drug tolerance in biomembranes: a spin label study of the effects of ethanol, Science 196, 684.
S. r. -s. -s. r. -s. r. -s. -s. -s. -s. r. P. -s. -s. , 1991). Some researchers have studied ethanol effects on liver composition in primates fed ethanol in liquid diets for periods ranging from 10 months to several years and, again, the results have been inconsistent. , 1981). This same group did, however, find decreases in 20:4n6 in whole liver preparations in this species following a shorter period of consumption (10 months). Therefore, the inconsistencies in the results may have reflected different methodologies, or some other undefined variable.
1991). Effects on calcium were attributed to cholesterol acting on a calcium channel and Ca2+ + Mg2+-ATPase. ,1981). ,1990). ,1991). ,1990). One interpretation of the effects of phosphatidylserine on synaptosomal calcium uptake is that the addition of phosphatidylserine produced a change in cholesterol domains, resulting in the increased calcium uptake. There have not been any studies that have examined effects of ethanol, either in vitro or chronic administration, on cholesterol domains and protein structure and function.
Alcohol, Cell Membranes, and Signal Transduction in Brain by Christopher D. Stubbs, Emanuel Rubin (auth.), Christer Alling, Ivan Diamond, Steven W. Leslie, Grace Y. Sun, W. Gibson Wood (eds.)